Endocrine Abstracts

Generally, after an initial active phase TED rarely reactivates. However, epidemiological evidence is scant. The following cases highlight the propensity for Graves’ orbitopathy to reactivate many years later.Case 1: A 69-year-old woman had Graves’ disease aged 29, and was reviewed in the TED clinic (ophthalmology, rheumatology and endocrinology), with reactivation of orbitopathy 40 years after initial disease. She was an ex-smoker, had hyperte...

Introduction: Cushing’s syndrome (CS) is a rare disease with incidence estimated 2-4 cases per million inhabitants per year. ACTH-dependent forms comprise up to 80% of all cases, of which 80% are central and 20% are ectopic, paraneoplastic forms of ACTH-dependent CS. Thymic neuroendocrine tumors (NET) are accounting for 0,4 - 3% of all NET’s with incidence of 0.02/100 000 inhabitants/year. Up to one third of them are hormonally active (secrete adrenocorticotropic hor...

Introduction: Androgen insensitivity syndrome rare X linked disorder that is typically characterized by evidence of feminization of the external genitalia at birth, abnormal secondary sexual development in puberty, and infertility in individuals with a 46,XY karyotype. Complete androgen insensitivity syndrome (CAIS) usually is recognized only at the teenage age due to primary amenorrhea. Recently, gonadectomy for patients with CAIS are postponed due to a mild risk of malignanc...

Background: Lifestyle is important in the treatment of type 2 diabetes. The aim of this study was to investigate whether a lifestyle programme through a smartphone application (digital therapeutic) could affect treatment outcomes at an endocrinology outpatient clinic.Methods: In this randomised controlled study, patients were consecutively invited to participate. Participants were randomly assigned to an intervention group or a control group. In addition...

Introduction: Immune-check point inhibitors (ICPis) has been shown to significantly improve survival in patients with advanced melanoma. Immune-related endocrinopathies (irEs) and in particular hypophysitis and thyroid dysfunction have been well described with an incidence varying from 9–17% and 3.8–13.2% respectively.Methods: This is a retrospective analysis of irEs in 325 (190 men) patients with melanoma receiving ICPis (PD-1/PDL-1 or CTLA-4 ...

Background: Metastatic pheochromocytomas (PCs) and paragangliomas (PGLs) are rare neuroendocrine neoplasms with a <1:106 incidence, defined by the presence of metastatic disease besides recurrent or locally invasive disease.Aim: Retrospective analysis of clinical, biochemical/hormonal, imaging, genetic and histopathological features of patients with malignant PCs/PGLs diagnosed over 15 years.Results: Thirteen patient...

Objectives: Adenosine is a purinergic mediator involved in the regulation of many physiological and pathological processes. It acts as neurotransmitter in the central and autonomic nervous system, where it counterbalanaces sympathetic activity. Adenosine is produced by majority of human cellsexerting autocrine, paracrine as well as systemic effects. Due toits vasodilatatory and negative inotropic effects it seems to play a role in ethiopathogenesis of orthostatic intolerance, ...

Background: During the last decennium, an increase in the number of persons referred to gender identity centres has been observed. Epidemiological data have not yet been formally studied in France. Here we report the experience from the Trans’Est Gender Identity Centre of the University Hospital of Nancy.Aim: To study the number of people seeking transgender care, the age at referral and the trends in the sex ratio.Methods: Th...

Pituitary adenomas (PAs) are benign neoplasms that comprise 10–20% of all intracranial tumors. Mutations in the aryl hydrocarbon receptor interacting protein (AIP) have been identified to cause a small subset of hereditary PAs. To study the mechanisms of tumor formation in patients with AIP-mutated PAs we conducted a miRNA array analysis comparing AIP-mutated PAs with AIP-wild type PAs. We found a novel and specific set of miRNAs differentially expressed between the two g...

Androgen ablation therapy remains the most common treatment for patients with advanced prostate cancer (PCa). However, most patients relapse and develop a castration-resistant PCa. The emergence of androgen receptor (AR) variants, such as constitutively active ARs, has been involved in this failure to androgen deprivation. Nevertheless, the tumour microenvironment is another necessary feature driving PCa progression. Cancer associated fibroblasts (CAFs) are one of the speciali...